Evaluation of immunological activities of an organic freeze dried inner leaf Aloe vera L powder - Vetvicka 2012 Rev 2012-7

Aloe vera L. (hereinafter referred to as “Aloe” or “Aloe vera”) has been used for millennia for medicinal purposes both topically and internally. Previous publications have shown a great deal of inconsistency of quality and therefore biological activity from commercially available Aloe vera products. The purpose of this study was to determine the immunomodulatory activity of an organic freeze dried inner leaf Aloe vera powder, which claims to have the highest immunomodulatory Acemannan (Beta 1,4 Acetylated Polymannan) fraction of the commercially available aloes. To accomplish this we chose well established biomarkers and a suitable model to measure phagocytosis, IL-2 production, antibody production, superoxide and nitrite production. The tests chosen were a combination of both in vivo and in vitro models using live mice as well as mouse and human cells. The results clearly demonstrated that BiAloe is a biologically active material in both cellular and humoral immunity.